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Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management - Pergolizzi - 2020 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

The combined action of these proteolytic systems accelerates muscle degradation, particularly in conditions of oxidative stress or inflammation ( 3.4 Chronic inflammation Chronic inflammation, also known as inflammaging, is a hallmark of aging and a major driver of sarcopenia

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If substantial progress appears at certain doses or with particular timing, maintain those variables