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Folic acid remains an effective way to support one-carbon metabolism and lower homocysteine in most people, while methylfolate may offer advantages for some individuals, particularly those with reduced DHFR activity or a poor response to folic acid

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Additionally, at least part of central ghrelin’s effects can be mediated by GH/IGF-1, as ghrelin stimulates systemic GH secretion and local GH expression in various brain regions