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Methods 30 , 256–268 (2003)

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Although some amino acid-degrading enzymes, such as asparaginase and PEGylated arginine deiminase, have already been used in the clinic to treat tumors (asparaginase) and show antitumor efficacy in human patients (arginase), additional therapeutic targeting of cancer metabolism has led to surprisingly few new drugs 31,32,33,34