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The Diagnostic and Statistical Manual of Mental Disorders IV-Text Revised (DSM-IV-TR) described autism as a complex neurobehavioral disorder characterized by varying degrees of social interaction deficits, flexibility of thinking, specific language abnormalities and/or delayed cognition, impaired verbal and non-verbal communication, failure to respond to certain stimuli with some restricted and extreme repetitive behavior or actions, stereotyped patterns of behavior or circumscribed interests, and association with several metabolic disorders