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Metformin also has indirect antitumoral effects due to its ability to reduce insulin and insulin-like growth factor 1 (IGF-1) levels and to influence metabolic pathways such as lipid metabolism and inflammation [15], which are known to promote HCC tumour growth and proliferation [162,163,164,165]

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[DOI] [PubMed] [Google Scholar] Liu RM, Gao L, Choi J, Forman HJ