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Meaningful hypertrophy is measured across years, not cycles Compounds that genuinely increase lean mass exist

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Next, we treated AC16 cells with increasing doses of rosiglitazone (25, 50, and 100 μM) and WY-14643 (25, 50, and 100 μM) to identify the minimum dose of rosiglitazone that increases PPARGC1A expression (Supplemental Figure 3, A–C) and the maximum dose of WY-14643 that does not (Supplemental Figure 3, D–F)