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The immune microenvironment within the LN is governed by a diverse array of immune cells, including macrophages, DCs, T cells, B cells, and non-immune cells like fibroblastic reticular cells, BECs, and LECs (169), structural remodeling of high endothelial venules (HEVs) (170, 171), enhanced recruitment of myeloid cells, and a reduction in effector lymphocytes (172) ( Figure 4C )

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ROS originate from normal cell metabolic processes as well as exogenous sources like ultraviolet or ionizing radiation, and chemicals