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Claims that B12 shots enhance energy, improve mood, or facilitate weight loss in people without deficiency are not supported by high-quality clinical trials
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Metformin , the first-line type 2 diabetes drug and an AMPK activator, has cognitive data that are observational and inconsistent, and it lowers BDNF, a growth factor the brain relies on and that exercise raises, which is a reason for caution in a healthy brain
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