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Therefore, some computational tools for predicting Kglu sites have been developed (Table 2)

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Scientific investigations have additionally demonstrated that FOXO4-DRI binds directly to the p53 transactivation domain 2 (TAD2), competitively displacing FOXO4 and triggering p53 nuclear exclusion, mitochondrial translocation, BAX activation and caspase-3-mediated apoptosis selectively within senescent cells