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Notably, conditioned medium from GLS1‑overexpressing microglia induced a mixed reactive phenotype in C8D1A astrocytes (elevated A1 markers C3 / Serping1 and A2 marker Ptgs2 ), dysregulated glutamate transporters (compensatory Eaat1 upregulation, Eaat2 downregulation), and increased pro‑inflammatory cytokines ( Il1β , Tnfα , Il6 ) (Fig

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LL-37 is a cationic peptide characterized by a helical structure that facilitates its interaction with microbial membranes